Endocrine Abstracts

Objective: In differentiated thyroid carcinoma (DTC), TSH suppression with levothyroxine (L-T4) is a standard treatment for reducing tumor recurrence after total thyroidectomy. This study aims to evaluate the effect of long-term TSH suppression on the development of sarcopenia and frailty in elderly patients with DTC.Method: Seventy patients aged 60 years and older with stable TSH levels during the last year and under L-T4 due to DTC were included in the...

GAPO syndrome (OMIM 230740) is a rare, multiple congenital anomalies syndrome characterized by Growth retardation, Alopecia, Pseudoanodontia and Ocular manifestations. Syndrome caused by anthrax toxin receptor 1 (ANTXR1) gene (NM_032208.2) mutation leading to deficiency of an enzyme involved in the metabolism and breakdown of extracellular matrix (ECM). Disease show parental consanguinity, autosomal recessive inheritance and since first description in 1947 a total of 38 patien...

Aim: Fibroblast growth factor (FGF) 21 is a hormone which plays an important role in metabolic diseases such as diabetes, obesity and dyslipidemia. In this study; we aimed to investigate the serum total and bioactive FGF21 levels in patients with gestational diabetes mellitus (GDM) and compared with healthy pregnant controls.Material and Methods: A two-step screening method and Carpenter and Coustan criteria were used in the diagnosis of...

Introduction: In recent years, it is thought that cardiovascular risk is increased in patients with nonfunctional adrenal insidentaloma (NFAI). There are not enough studies in the literature that evaluating this condition in patients with NFAI who don’t have traditional cardiovascular risk factors. The aim of our study is to determine peripheral and central blood pressures and arterial stiffness in patients with NFAI who don’t have traditional risk factors and autono...

Introduction: Polycystic ovary syndrome (PCOS) is the most common endocrine pathology in premenopausal women and it is a complex syndrome affecting various systems. Numerous studies have been made about how the PCOS effects on bone metabolism, but currently there is no clear information. Wnt pathway plays important role in the regulation of bone metabolism. The sclerostin(Scl) and Dickkopf-1 (DKK1) inhibit this pathway and they has recently become a therapeutic target of osteo...

Objective: The aim of the present study was to evaluate cardio metabolic risk factors in patients with non-functional adrenal adenoma.Materials and methods: We studied thirty newly diagnosed adrenal adenoma patients and 30 healthy participants. Fasting glucose, insulin, lipid, hormone profile were evaluated from each patient.Results: The frequency of diabetes mellitus and hypertension were statistically higher in adrenal adenoma gr...

Insulinoma is generally a rare benign tumor of the pancreas islet cell. The typical clinical symptom of insulinoma are repetitive hypoglycemia attacks. Insulinoma with coexisting diabetes is extremely rare condition, We aim to present a case with insulinoma conmomittant with type 2 diabetes mellitus.Case report: A 65-year-old woman diagnosed with type 2 diabetes mellitus was admitted by our internal medicine clinic. She complained from perspiration and t...

Introduction: The neuropathies are one of the most common complications seen in diabetes, affecting up to 50% of diabetic patients. Isolated or combined paralysis of 3rd, 4th and 6th cranial nerve can be seen.Case presentation: Sixty-six-year-old male patient was admitted to the neurology department with the complaints of diplopia persisting for 15 days. Cranial images revealed no abnormal findings. Patient was directed to internal medicine clinic due to...

Introduction: The effects of sex steroids on lymphocytes count and functions are well known and it is propounded that autoimmune diseases more common in women. NLO index is an indicator of inflammative situation. In this study, it has been aimed that neutrophil/lymphocytes ratio (NLO) calculation by determining neutrophil/lymphocytes values in patients who diagnosed as hypogonadotropic hypogodanism and searching that whether there is significant difference between healthy grou...

Aim: Thyroid hormones act both insulin agonistic and antagonistic in different organs. Studies that evaluate the relationship between insulin resistance and hypo-hyperthyroidism have conflicting results, even euthyroid status was shown to change insulin sensitivity. In this study, our aim is to investigate the association between TSH, free T4, free T3 levels and insulin resistance in euthyroid patients.Method: Euthyroid 57 males, 47...